Creatine is an osmotically active substance. Thus, a rise in the body’s creatine content might theoretically end in increased water retention. Creatine is taken up into muscle from circulation by a sodium-dependent creatine transporter [1]. Because the transport involves sodium, water will even be taken up into muscle to assist maintain intracellular osmolality. Nonetheless, contemplating the exercise of the sodium-potassium pumps, it’s not going that intracellular sodium focus is dramatically affected by creatine supplementation [39].

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