Ls-models.rar 📂
公開日:2022/06/17 / 最終更新日:2022/06/17
Ls-models.rar 📂
Ls-models.rar
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The maruti a-star, ls-led rar, ls-na and ls2 front. ls-ls420 models, parts  .PROJECT SUMMARY Our goal is to advance a novel nanoscale biosensing platform that can rapidly detect and reveal the structure of biologically important molecules in the presence of biological specimens. Our target, antigen-specific B cells, are distinguished from others by their unique antigenic specificity. This extraordinary specificity of B cells enables them to react to a specific antigen and to differentiate into the antibody-secreting plasma cell when antigen is introduced into the body. We hypothesize that a biosensing platform can detect antigen-specific B cells and can reveal their antigen specificity. We propose a two-step Nanofluidic Interrogation of antigen-specific B cells (NanobiFluidics) to address these challenges. First, we will develop a new biosensing technology that enables us to rapidly and selectively detect single antigen-specific B cells, and to reveal their antigen specificity in the presence of biological specimens (Aim 1). In the second step, we will use the technology developed in Aim 1 to create the first nanoscale biosensing device to identify the structure of antigen in the presence of immunoglobulins (IgG) (Aim 2). We expect that these goals will lead to a new technology for rapid and sensitive evaluation of antigen-specific B cells in the body and to development of a protein-typing technology capable of typing any protein in biological specimens. This research will be performed in collaboration with two outstanding collaborators, Dr. Jason Axton and Dr. George Kleikamp. The proposed work combines the nanotechnology expertise of Dr. Zhenkun Lou, the diagnostics technology expertise of Dr. Jason Axton, and the expertise in clinical applications of Dr. George Kleikamp. Dr. Zhenkun Lou has more than 15 years of experience in developing nanoscale devices and has demonstrated the capability of using nanoparticles to detect and discern different biomolecules in the presence of biological specimens. Dr. Jason Axton has conducted successful research on antigen-specific B cell detection and has solved the challenge of surface analysis of cells and their immunoglobulins, and has confirmed that the nanoscale biosensing platform is feasible. Dr. George Kleikamp has expertise in cell typing and has validated that NanobiFluidics can reveal the structure of antigen in the presence of IgG
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