The Invention Of The Vitamins – PubMed
公開日:2022/06/02 / 最終更新日:2022/06/02
The invention of the vitamins was a major scientific achievement in our understanding of health and disease. In 1912, Casimir Funk initially coined the term “vitamine”. The most important interval of discovery started within the early nineteenth century and ended at the mid-twentieth century. The puzzle of every vitamin was solved by means of the work and contributions of epidemiologists, physicians, physiologists, and chemists. Reasonably than a legendary story of crowning scientific breakthroughs, the reality was a gradual, stepwise progress that included setbacks, contradictions, refutations, and some chicanery. Analysis on the vitamins which can be associated to main deficiency syndromes began when the germ concept of illness was dominant and dogma held that only four nutritional components were essential: proteins, carbohydrates, fats, and minerals. Clinicians quickly recognized scurvy, beriberi, rickets, pellagra, and xerophthalmia as particular vitamin deficiencies, relatively than diseases resulting from infections or toxins. Experimental physiology with animal models played a basic function in nutrition research and greatly shortened the interval of human affected by vitamin deficiencies. In the end it was the chemists who isolated the assorted vitamins, deduced their chemical construction, and developed methods for synthesis of vitamins. Our understanding of the vitamins continues to evolve from the preliminary period of discovery.
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