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公開日:2022/02/03 / 最終更新日:2022/02/03
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Human depression results from a mix of genetic susceptibility and environmental factors, equivalent to stress. Anhedonia, the lack to expertise pleasure from beforehand fulfilling actions, is a core symptom of depression. Like human depression, numerous types of chronic stress induce an anhedonic state in rodents, which is characterized by attenuated behavioral responses to beforehand rewarding stimuli (15). Importantly, responses to rewarding stimuli in careworn animals are restored by compounds that have antidepressant efficacy in people, including fast- and gradual-acting compounds corresponding to ketamine and selective serotonin reuptake inhibitors (SSRIs), when administered acutely and chronically, respectively (16).
The exact same traits that led to the incorporation of hallucinogens into ritualistic or spiritual traditions have also led to their propagation as medication of abuse. Importantly, and in contrast to most different drugs, the effects of hallucinogens are highly variable and unreliable, producing completely different results in different individuals at totally different occasions. That is mainly because of the numerous variations in amount and composition of active compounds, notably in the hallucinogens derived from plants and mushrooms. Because of their unpredictable nature, the usage of hallucinogens might be notably dangerous.
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